Multichannel fiber optic monitor for real time concentration measurement
Name of applicant
Annette Bauer-Brandl
Title
Professor
Institution
University of Southern Denmark
Amount
DKK 771,557
Year
2022
Type of grant
Research Infrastructure
Summary
Millions of animal experiments are still used in drug development each year. We want to save animal experiments in this field. By employing the fiber optic concentration monitor, we can study the dissolution process of drugs in detail. This process is crucial for bioavailability and effectiveness of drugs. We shall study the physico-chemical processes that take place at the surface of drug particles. We will also develop fully artificial models that mimic the conditions in vivo that will enable us to explore many drugs and dosage forms (e.g. amorphous solid dispersions, oral films), for time resolved absorbable fractions. This will pave the path from empiric drug development with many animal tests towards informed computational modelling to find the best drug formulations.