Infrastructure for Circular DNA Genomics
Name of applicant
Birgitte Regenberg
Institution
University of Copenhagen
Amount
DKK 451,700
Year
2021
Type of grant
Research Infrastructure
Summary
The grant will be essential for our research which focuses on: 1. Investigation of the factors causing DNA circularization with yeast as a model organism. 2. Completing an Atlas of the tissue-specific composition of circular DNA in mammalian development and ageing using mouse as a model organism. 3. The detection of circular DNA in humans disease: - In pancreatic, lung and colorectal cancers which have large unmet needs for circular DNA methylation profiling, and detection of circular DNA copy number variations. - In neurodegenerative disorders such as amyotrophic lateral sclerosis, since our preliminary studies suggest a role of circular DNA in these diseases. 4. New and more efficient methods for isolation and mapping of circular DNA. 5. Chromosomal evolution in yeast and mammals.