Targeting Solute Carriers using Recombinant Antibodies.
Name of applicant
Peter Kristensen
Institution
Aalborg University
Amount
DKK 1,585,500
Year
2021
Type of grant
Research Infrastructure
Summary
Membrane proteins play an essential role in translating extracellular cues into intracellular responses, a feature making them attractive drug targets. Thus, it is not surprising that while membrane proteins make up around 30% of human genes, they account for over 60% of all drug targets. The solute carrier (SLC) superfamily constitutes the largest group of membrane proteins, transporting a vast array of important molecules across membranes. This superfamily of membrane proteins include more than 450 proteins. Despite being attractive and druggable targets, the SLCs, for a major part, remains understudied. Availability of reliable and validated tools to study the distribution, function and behavior remain a major bottleneck. In the current project we select recombinant antibodies for SLCs.