An 80 MHz benchtop NMR spectrometer for flow chemistry applications

Chemistry and enzymatic reactions are often performed in batches for a certain time. It is beneficial instead to perform reactions in a flow reactor. A powerful analysis method to elucidate the outcome of reactions is NMR spectroscopy, where the sample is placed in a strong magnetic field and irradiated with radio frequency signals. The project will develop NMR methods on a small NMR instrument, which can monitor the reactions in real time by passing output of a flow reactions directly into the instrument. The project aims to elucidiate and optimize both enzymatic conversion of polysaccharides and a variety of chemical transformations. The improved reactions will be of significant importance for application in medicinal chemistry and better utilization of renewable resources.