Molecular determinants of membrane protein orchestration

All cells contain membrane proteins, which are involved in many things, such as flow of nutrients, and communication between cells. When dysfunctional, they can cause many different diseases. Membrane proteins are usually studied in isolation, but in life they exist in and are dependant on the cellular context for correct function. Hence, our goal is to increase understanding of these cellular contexts, focusing on proteins that control ion passage across biological membranes and how they are regulated. To enable sufficient protein production, using a fermenter will be necessary, which the current proposal will enable us to acquire. It will allow us to show protein complex formation and how it controls ion flow, deepening our understanding of human health and disease.