Deciphering Lipoxin Signaling Mechanisms and Their Role in Modulating Lymphatic Inflammation
Navn på bevillingshaver
Emma Börgeson
Titel
Associate Professor
Institution
Aarhus University
Beløb
DKK 7,000,000
År
2024
Bevillingstype
Semper Ardens: Accelerate
Hvad?
The lymphatic system emerges as a crucial tissue to resolve inflammation. Our recent data suggest that bioactive lipids of the lipoxin family may act specifically on the lymphatics to promote resolution of adipose tissue inflammation. We found that lipoxin B4 was especially potent in its action, but its biology, receptor and specific differences to effects of Lipoxin A4 remain unknown.
Hvorfor?
Impairment of inflammatory resolution remains an understudied mechanism in immune biology, especially for the development of chronic disease conditions. Many of the molecular mechanisms that underly inflammatory resolution, involve bioactive lipids of the lipoxin family, whose biology, agonist function for G-protein coupled receptor activation and signaling remain to be further elucidated.
Hvordan?
This project combines state-of-the-art techniques and model systems to answer fundamental questions in resolution and immune biology. Combining our expertise of lipoxin actions in vivo, with that of our collaborators on lymphatic functions and the quantification of metabolites and lipids in biological samples will provide novel insights into the biology of pro-resolving bioactive lipids.